Modulation of Myostatin/Hepatocyte Growth Factor Balance by Different Hemodialysis Modalities

نویسندگان

  • Pasquale Esposito
  • Edoardo La Porta
  • Marta Calatroni
  • Maria Antonietta Grignano
  • Samantha Milanesi
  • Daniela Verzola
  • Yuri Battaglia
  • Marilena Gregorini
  • Carmelo Libetta
  • Giacomo Garibotto
  • Teresa Rampino
چکیده

Background. In this study we investigated the relevance of myostatin and Hepatocyte Growth Factor (HGF) in patients undergoing hemodialysis HD and the influence of different HD modalities on their levels. Methods. We performed a prospective crossover study in which HD patients were randomized to undergo 3-month treatment periods with bicarbonate hemodialysis (BHD) followed by online hemodiafiltration (HDF). Clinical data, laboratory parameters, and myostatin and HGF serum levels were collected and compared. Results. Ten patients and six controls (C) were evaluated. In any experimental condition myostatin and HGF levels were higher in HD than in C. At enrollment and after BHD there were not significant correlations, whereas at the end of the HDF treatment period myostatin and HGF were inversely correlated (r  -0.65, p < 0.05), myostatin serum levels inversely correlated with transferrin (r  -0.73, p < 0.05), and HGF levels that resulted positively correlated with BMI (r 0.67, p < 0.05). Moving from BHD to HDF, clinical and laboratory parameters were unchanged, as well as serum HGF, whereas myostatin levels significantly decreased (6.3 ± 4.1 versus 4.3 ± 3.1 ng/ml, p < 0.05). Conclusions. Modulation of myostatin levels and myostatin/HGF balance by the use of different HD modalities might represent a novel approach to the prevention and treatment of HD-related muscle wasting syndrome.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Muscle Atrophy Reversed by Growth Factor Activation of Satellite Cells in a Mouse Muscle Atrophy Model

Muscular dystrophies comprise a large group of inherited disorders that lead to progressive muscle wasting. We wanted to investigate if targeting satellite cells can enhance muscle regeneration and thus increase muscle mass. We treated mice with hepatocyte growth factor and leukemia inhibitory factor under three conditions: normoxia, hypoxia and during myostatin deficiency. We found that hepato...

متن کامل

The Effect of 8 Weeks of Resistance Training with and Without Blood Flow Restriction on Serum Levels of Insulin-like Growth Factor-1 and Myostatin of Athletic Girls: A Semi-Experimental Study

Background and Objectives: Insulin-like growth factor-1‎ (IGF-1) and myostatin play an important role in responding to muscle contractions, regulating and stimulating muscle metabolism. Therefore, the aim of this study was to investigate the effect of 8 weeks of resistance training with and without blood flow restriction on IGF-1‎ and myostatin of female athletes. Materials and Methods: In thi...

متن کامل

Application of myostatin in sheep breeding programs: A review

Myostatin or growth and differentiation factor 8 (GDF8), has been known as the factor causing double muscling phenotypes in which a series of mutations make the myostatin protein inactive, hence disabling it to regulate the deposition of muscle fibre. This phenotype happens with high frequency in a breed of sheep known as the Texel. Quantitative trait loci (QTL) studies show that a portion of t...

متن کامل

Investigation of GDF8 Gene Promoter in Iranian Sheep

Myostatin is a growth factor belonging to the TGFß superfamily. TGFß growth factors are active in the regulation of embryonic development and in tissue homeostasis in adults. Myostatin is a growth factor controlling proliferation of myoblasts in embryonic development. Mutations in coding sequences of the bovine myostatin (GDF8) gene lead to muscle hyperplasia suggesting its inhibitory function ...

متن کامل

Myostatin inhibits IGF-I-induced myotube hypertrophy through Akt.

Myostatin is a highly conserved negative regulator of skeletal muscle growth. Loss of functional myostatin in cattle, mice, sheep, dogs, and humans results in increased muscle mass. The molecular mechanisms responsible for this increase in muscle growth are not fully understood. Previously, we have reported that phenylephrine-induced cardiac muscle growth and Akt activation are enhanced in myos...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 2017  شماره 

صفحات  -

تاریخ انتشار 2017